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Findings such as these may suggest a neuroprotective role for siponimod in the CNS, by countering MIMS and AIMS development, and justify its feasibility as a therapeutic option in SPMS (163)

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Springer J, Scholz FR, Peiser C, Groneberg D, Fischer A: SMAD-signaling in chronic obstructive pulmonary disease: transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke