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Overall, preclinical studies have shown that NAD + and mitochondrial metabolism play a crucial and intertwined role in aging and age-associated diseases, as well as being possible therapeutic targets for ameliorating these conditions

FIGURE 2 Under the conditions of Ca 2+ influence in the concentration range of 10 7 10 4 mol/L, a dose-dependent swelling of mitochondria isolated from rat heart tissue was observed (Figure 2B)

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Rats receiving either NAC or NACET eye drop treatment had greater ONL thickness compared to vehicle treated rats, and resembled healthy, age-matched controls along both superior and inferior poles (Fig