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A study found that tissue retention of most inhaled drugs was lower in lung epithelial cells of cancerous rats in comparison to Caco-2 cells, which consist of inhibited ABC transporters that mimic human cells (Eriksson et al

Prev Med 54, Suppl., S4S8

Furthermore, by preserving mitochondrial functional homeostasis, it has been observed that the iron-overload inhibitors UAMC-3203 and VBIT-12 both mitigate ferroptosis in the model [230]

In contrast to fission, the primary mediators of mitochondrial fusion are anchored on the mitochondrial membranes, including optic atrophy protein-1 (OPA1) residing on the inner membrane, and mitofusin-1 and -2 (MFN1/2) on the outer mitochondrial membrane (69)