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Furthermore, the fraction of oral vitamin C that is not absorbed passes into the large intestine where it draws in water and can cause loose stools the familiar gastrointestinal side effect of high-dose oral supplementation

doi: 10.1523/JNEUROSCI.0542-11.2011, 47 KochG.MartoranaA.CaltagironeC
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The decrease of lymphocyte interferon gamma expression during aging is one of the main mechanisms leading to the immunodeficiency
