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Further investigation showed that the N-terminal F 4 XXR 7 motif of LYSET interacts with the COPI adaptor GOLPH3, a key factor in maintaining the LYSET-GNPT complex at the Golgi

For drug design, its important for LogP to enable effective absorption and distribution across biological membranes while keeping enough water solubility

Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im DS, Kuwabara A, Mogi C, Itoh H, Kurose H, Murakami M, Okajima F