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Pathak treated an atherosclerotic mouse model with iodomethylcholine (IMC), a mechanism-based inhibitor of choline TMA lyase, and the loss of neutral sterols in mice feces was identified in the form of coprostanol (a bacterial metabolite of cholesterol) (83)

Research shows treated animals lost an average 5.1% body weight, 30% reduction in adipocyte size and 35% decrease in white adipose tissue mass

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