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In addition to direct therapeutic effects, chemically modified SeNPs can also serve as carriers, conferring favorable properties to the carriers, such as tumor targeting (248), high efficiency (249) and low toxicity (250)

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Patients with an isolated CNS relapse who show greater than 0.01% MRD in a morphologically normal marrow have a worse prognosis (5-year EFS rate, 30%) than do patients with either no MRD or MRD less than 0.01% (5-year EFS rate, 60%).[218] Isolated CNS relapse Standard treatment options for childhood ALL that has recurred in the CNS include the following: Systemic and intrathecal chemotherapy