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Description
While stress is a main component of a suppressed immune system there are plenty of other factors that influence the lining of the gut itself - factors such as prolonged exposure to antibiotics, inflammatory foods, toxins, etc

However, there is limited clinical evidence establishing a direct causal link between berberine supplementation and constipation specifically

10.3390/nano14161331 27 DattaA

247, Accessed 19 Nov
