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Oxidative stress is a physiological condition in the system where the outputs of reactive oxygen species (ROS) tends to alter the vigor of antioxidant systems at either the cellular or system level ( Increased level of oxidative products like thiobarbituric acid reactive substances and Malondialdehyde ( Endogenous antioxidant enzymes SOD and CAT that make up the antioxidant cellular enzymatic system, function as the first line of defense and are important indicators of the oxidation status of animal tissues ( 2 ) into hydrogen peroxide (H 2 0 2 ) and an oxygen molecule (O 2 ) to reduce the damage caused by the former
Lastly, despite PDE5i treatment has been proven a cost-effective therapeutic strategy, compared to no treatment [62], the relatively high cost of a chronic treatment with some reference/equivalent pharmaceutical formulations belonging to this category of drugs might still represent a limitation for patients with economic constraints, by contributing to treatment discontinuation

doi: 10.2147/IMCRJ.S74563
