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In general, more widespread disease, or disease affecting internal organs, is treated with systemic therapy with interferon alpha, liposomal anthracyclines (such as liposomal doxorubicin or daunorubicin), thalidomide, or paclitaxel

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Jin H, Jeong M, Lee G, Kim M, Yoo Y, Kim HJ, Cho J, Lee Y, Lee H

Congestive heart failure: Sensations of rapid or irregular heartbeat are symptoms of heart failure and are caused by the heart overcompensating for its diminished pumping capacity