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While malondialdehyde and myeloperoxidase levels in the liver tissue samples increased significantly in the 2nd group, those levels were determined to be decreased significantly in all treatment groups
This is important because rapid IV administration can lead to sudden shifts in electrolytes particularly potassium which may result in hypokalemia and, in severe cases, cardiac complications
We conclude that intracellular pyruvate, or other -ketoacids, whose endogenous concentration is controlled by metabolism, have little role in H2O2 clearance
