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Of note, only the combination of ALOX12 knockdown and ferrostatin treatment reduced lipid peroxide levels below the levels observed in uninfected neighboring cells, again indicating that this combined intervention is required to lower lipid peroxide levels sufficiently to inhibit ZIKV infection
In healthy male volunteers, Spirulina treatment (200 mg/day for 56 days) increased CD4 + T-helper cell proliferation and elevated Th1-type cytokine production (TNF-, IL-2, IFN-), while partially inhibiting Th2 cytokines such as IL-4, with no effect on IL-10 [122]
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