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There were promising signs of target engagement, providing grounds for further exploration of the mechanism Similar content being viewed by others Introduction Autonomic nervous system (ANS) imbalance, including increased sympathetic nervous system (SNS) activity and decreased parasympathetic nervous system (PNS) tone, is present in numerous cardiovascular diseases such as heart failure (HF) 1,2,3

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Similar evidence has been observed more recently in two small studies that suggest G6PD deficiency may decrease the risk of coronary heart disease and cardiovascular associated death (15, 67)

Here we use the most recently proposed PRX classification system, that identifies six subfamilies, of which three occur in animals, based on protein sequence similarities at the peroxidatic cysteine (C P ) active site 41,42 (Table S3)