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International Journal of Stroke, 11(3), 347-355
Science 332 , 586589 (2011)
ROS stimulates the activity of many physiological components, including mitogen-activated protein kinases (MAPK), tyrosine kinases, Rho kinases, and transcription factors (NF-kB, AP-1, and HIF-1) and increased concentration of intracellular free Ca 2+ also inactivates the protein tyrosine phosphatases (PTP)
114,115 NF-B activates proinflammatory genes encoding cytokines and chemokines, such as IL-1, IL-8 and TNF-
