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These toxicities can affect nearly any organ system but most commonly manifest as dermatologic toxicity, endocrinopathies, and severe autoimmune colitis , which requires prompt recognition and management with systemic corticosteroids
ClinicalTrials.gov (2020)

5I), indicating that the Ufd4-mediated K29-linked ubiquitin chain is not involved in the RQC induction

Michels J, Venkatesh D, Liu C, Budhu S, Zhong H, George MM, et al
