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These enzymes are the pyruvate dehydrogenase complex (PDHc) and 2-oxoglutarate (-ketoglutarate) dehydrogenase (OGDH), both of which are associated with the TCA cycle, and branched-chain ketoacid dehydrogenase (BCKD) necessary for metabolism of the branched-chain amino acids, leucine, isoleucine, and valine

As discussed before, AD is a multifactorial condition and therefore numerous factors (both hereditary and lifestyle) apart from A accumulation itself can contribute to or pose a risk to the development of this neurodegenerative disease [85, 86]

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Shao et al., 2017)