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C-reactive Protein and the Coronavirus C-Reactive Protein and Inflammation C-reactive protein (CRP) discovered in 1930 by Tillett and Francis Jr is an acute-phase pattern recognition protein (PRP) considered to be a sensitive biomarker of systemic inflammation, mainly produced by liver hepatocytes, secondary to cytokine stimulation (i.e., IL-6, IL-1 or TNF-) (113115) that increases 1,000-10,000-fold at sites of infection or inflammation within 24-72 hours (114, 116126), from the 0.8 mg/L found in healthy young adult individuals (119)

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Second, pineal dysfunction in AD results in reduced melatonin production, which finally triggers sleep disturbance and poor sleep quality in AD