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For instance, building upon the established role of GPX4 in suppressing ferroptosis in alveolar cells, the demonstrated therapeutic potential of mesenchymal stem cell-derived exosomes, the feasibility of CD44-mediated macrophage targeting, and the precedent for pulmonary nucleic acid delivery, the engineering of inhaled exosomes to deliver GPX4 mRNA specifically to alveolar macrophages represents a promising frontier (175, 178)

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The SUOX gene is located on chromosome 12q13.2 and is composed of 8 exons that generate three alternatively spliced mRNAs, each of which encode the same 545 amino acid protein