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Congenital IGF-1 deficiency may result from GH gene deletion, GH releasing hormone (GHRH) receptor defects and IGF-1 resistance
Tiwari M, Kidwai M, Dutta P, Narayan S, Gautam N, Chawda K, Shirke PA, Mishra AK, Chakrabarty D

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Patients maintained an average ketone level of 6.4 mmol/l during the 12-week period