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Although direct verification of this framework remains challenging, existing research provides strong support for its plausibility

Nat Rev Genet 18:164179

Research peptide studied for ghrelin receptor and growth hormone signalling pathways

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective