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These processes are regulated by oncogenic alterations such as EGFR amplification, PTEN loss, and HIF-1 stabilization, which allow tumor cells to thrive in hypoxic and nutrient-poor environments

In susceptible hair follicles, DHT binds to the androgen receptor (AR) resulting in the activation of genes responsible for the transformation of anagen to catagen and the conversion of large terminal follicles to miniaturized follicles[5,6]

D., Naur, P

M., Mendes M
