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Vitamin K is essential in the carboxylation of Vitamin K dependent proteins (VKDP), particularly osteocalcin (OC) and MGP that regulate extracellular matrix mineralization, osteoblast differentiation, and osteoclastogenesis (121)

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Taking a vitamin B complex is recommended because there is evidence that a combination of neurotropic B vitamins is more effective than taking a single vitamin B supplement, due to the synergies between the different vitamins.

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