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In human embryonic kidney cells, persistent TNF- stimulation activates TET enzymes, which demethylate the CALCB enhancer and IL32 promoter, establishing a trained-like transcriptional state (170)

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Rosrio M, Birchmeier W

Regulatory framework for epigenetic therapies NcRNA-based epigenetic therapies occupy a regulatory gray area: they are neither traditional small-molecule drugs nor permanent genomic modifications, but they may reconfigure cellular networks in ways that resonate throughout generations