glutathione conjugation enzyme Glutathione-Mediated of Anticancer Drugs: An Overview of Reaction Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Glutathione Conjugation
Description
During osteoclast differentiation, the antioxidant arctigenin inhibits RANKL-induced MAPK activation and the activation of transcription factors such as NF-B and NFATc1 in a dose-dependent manner, thereby suppressing the differentiation and maturation of osteoclast precursors
This signaling is characterized by increased intrinsic and extrinsic signaling involving Bax/BcL-2 proteins, leading to the loss of NK1 receptors after 40 days of PD induction, which results in breathing dysfunction (Falquetto et al., 2020)
doi: 10.1186/s42269-021-00635-6 24
R.PetrovaB.WaruiD
