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Description
Twenty-five unique selenoproteins have been discovered in humans, including five types of GPXs, three types of thioredoxin reductases, and selenoprotein P in plasma [249,250]
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118 Accumulation of fumarate inhibits the KDM5 family of histone demethylases, increasing the levels of the active gene transcription marker H3K4me3

7 Curr Drug Targets
Researchers utilize this mechanism to explore downstream effects on SIRT1 activation, which is a critical regulator of mitochondrial biogenesis, fat oxidation, and glucose metabolism
