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This antitumorigenic effect is mediated through the activation of cyclin-dependent kinase inhibitors specifically p21 & p27, which disrupt the action of mitogenic growth factors such as insulin-like growth factor 1 (IGF-1) and epidermal growth factor (EGF), while simultaneously enhancing the tumour-suppressive effects of transforming growth factor-beta (TGF-)

In addition, more research into the effects of age, sex and species or strain on the outcome of TBI is necessary

Microglia have been classically divided into two activation phenotypes, M1 (classical activation phenotype) and M2 (alternative activation phenotype) (Luo and Chen, 2012)

GABA receptor classification and structure GABA receptors respond to the ligand GABA, which is the main inhibitory neurotransmitter in the mammalian central nervous system