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Chamomile contains apigenin, a naturally occurring flavonoid that has been shown to interact with benzodiazepine receptors in the brain, which are involved in regulating relaxation and sleepwake cycles

Many companies rely on third-party experts to audit draft responses, and the FDA itself has increasingly encouraged this approach when internal expertise is insufficient

This means most of a high-dose supplement remains in the gastrointestinal tract, though the direct link to digestive symptoms is not well established

Jumping directly to the maintenance dose significantly increases the risk of gastrointestinal side effects