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10 Outlook 10.1 Future directions in brain energy metabolism research As we advance our understanding of brain energy metabolism, the emerging research trends and unsolved scientific questions reveal several promising avenues for future exploration

Importantly, decreased NRF2 activity and GSH levels in resistant cells were a direct consequence of acquiring the T790M mutation as introducing EGFRm/T790M in HEK293 cells, rather than EGFRm alone, reproduced the changes associated with erlotinib resistance (Figure 4ac)