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Description
The question researchers keep returning to is whether restoring GH pulsatility in aged subjects reverses measurable functional decline in muscle, bone, and metabolic parameters, or whether the somatopause itself reflects a broader neuroendocrine recalibration that GH restoration cant fully address
Recently, the association between central nervous system (CNS) diseases and ERGO has become a research focus

Many key enzymes of metabolic pathways can be regulated via specific and reversible oxidative modifications that act as thiol switches (Brandes et al., 2019

The Journal of Neuroscience, 18, 29442953
