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A major step toward understanding this relationship occurred when we determined that the AT4 receptor antagonist Norleual-AngIV (Nle-Tyr-Leu-(CH2-NH2)3-4-His-Pro-Phe) inhibited HGF binding to Met and HGF-dependent cell signaling, proliferation, invasion, and scattering [81]

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assessed the longitudinal association between serum UA level and an incidence of dementia in a study involving 1,598 healthy participants, with available brain MRI data, who were followed for 12 years [117]