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[DOI] [PubMed] [Google Scholar] 230.Mercado G, Valdes P, Hetz C
[DOI] [PMC free article] [PubMed] [Google Scholar] Maghraby, A
The chapter also reviews other mechanisms involved in the long-term effects of opioids, such as neuroplasticity, changes in neurotransmitter release, activation of anti-opioid systems, and neuroinflammation
It is often advisable to start with a lower dose (e.g., one capsule daily) and gradually titrate up to the full dose as tolerated
