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however, their multi-targeted effects may lead to systemic side effects such as myelosuppression and liver and renal toxicity, and lack of lesion-specificity, which predispose to elevated infection risk.131133 The core difference between the two lies in the mode of action: Hypericin relies on light-activated local targeting, whereas synthetic drugs are based on systemic immunosuppression, presenting the challenge of balancing efficacy and safety

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