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It was also reinforced the idea that neutral bulky substituents with few active torsions in the ligands scaffold contributed more effectively to achieve favorable enzyme-ligand interactions

In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression

5.6.3 Heterogeneity of patient populations Baseline heterogeneity is pronounced