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Cobalt sensitivity reactions can result in different symptoms, such as chronic or subacute allergic contact dermatitis, which can occur immediately or up to 72 hours after administration, but the likelihood of a cobalt allergy is low and affects between 1% and 3% of the general population

The safety profile appears favorable for extended use based on available data, though long-term studies specifically on oral formulations do not exist

Benson, D
