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Description
Animal Model:Ischemia (pMCAO) rats [4] Dosage:100 g/kg Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO)
11 The main pathological feature of PD is the buildup of toxic -synuclein, a protein that forms into insoluble fibrils called Lewy bodies
The study was further extended by synthesizing a series of ( E )-2-((substitutedphenyl)diazenyl)phenyl-4-methylbenzenesulfonate ( 12a b ) and (E)-2-((substituted phenyl)diazenyl)phenol derivatives ( 12c d ) (Figure 6) and most of the compounds were strongly inhibit the tyrosinase in a dose-dependent manner
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