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Trials 23 , 170 (2022)

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34 Risk factors for the development of hyperammonaemia whilst undergoing therapy with VPA include the concomitant use of other antiepileptic drugs, concomitant use of mood stabilizers, genetic variability, poor nutritional status, inborn errors in carnitine metabolism and errors in metabolism of urea, and the use of certain HIV medications

These are often ingredients that affect your brains acetylcholine levels, like huperzine A
