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This accumulation impairs the hairs ability to produce pigment by reducing the expression of key antioxidant enzymes like catalase and methionine sulfoxide reductases A and B

Pettegrew J, Levine J, McClure R

The stress-inducible protein heme oxygenase-1 expressed in human gingival fibroblasts exposed to nicotine was overcome by the addition of the glutathione precursor N-acetyl-L-cysteine 8

Weaver L, Rostain AL, Mace W, Akhtar U, Moss E, OReardon JP
