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Description
When the requirement for NADPH outweighs the need for ribose, for example in adipose tissue where there is a large demand for NADPH for fatty acid biosynthesis, the pathway operates as a cycle, generating NADPH and CO2 and returning 5/6 of the carbon to the glycolysis pathway via fructose-6-phosphate and glyceraldehyde-3-phosphate

In Barth syndrome, this translates into measurable gains in cardiac function and walking distance

10.1073/pnas.1505556112 254 RoosJ.DiGregorioP

Several methods can be used to evaluate body composition, with different outcomes on precision and accuracy
