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35 Flupirtine was synthesized and first approved in Germany in the 1980s and is a triaminopyridine derivative with the chemical structure of 2-amino-3-ethoxy-carbonylamino-6-4-fluoro-benzylamino-pyridine

*Correspondence: Xiaoyulong Chen, [email protected] This article was submitted to Invertebrate Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Furthermore, NLRX1 overexpression enhances mitochondria-derived reactive oxygen species (ROS) generation in response to cisplatin exposure, resulting in excessive autophagy activation (Yin et al., 2018)