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The pathogenesis involves both innate and adaptive immune responses targeting bile duct cells and various extrahepatic tissues [241,242,243]
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To inhibit integrin 21-mediated collagen binding, sEVs were pre-incubated with 2 M TCI-15 (TOCRIS, Oxfordshire, UK) at 37 C for 1 h
Biotechniques 30 , 116120 (2001)
