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Among the different NEDA parameter candidates, plasmatic biomarkers for CNS lesion are showing promising results, such as neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP)

GKT137831 has demonstrated potential in preclinical studies to reduce cardiovascular complications, but current clinical trials on this agent lack evaluation of macrovascular outcomes, highlighting the need for longer-term studies in this setting

Although some treatments exist to reduce pain and damage, there is a lack of effective means to promote cartilage regeneration
