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In studies combining NNMT inhibition with progressive weighted wheel running (an intensive concurrent endurance and resistance exercise protocol), treated mice exhibited sustained enhanced muscle performance suggesting reduced need for recovery between exercise sessions
83 Moreover, H4K12la in PC9-BrM3 cells facilitates CCNB1 transcriptional activation, which accelerates DNA replication and the cell cycle, promoting acquired resistance to pemetrexed in lung cancer-derived brain metastasis
doi: 10.1038/nrm4048
