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The CYP2E1-induced oxidative stress increases the intracellular GSH level by increasing the activation of GCS through Nrf2 nuclear translocation [74, 75, 84, 17]

A.s 2025 study, Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver, chronic alcohol consumption significantly alters liver enzymes crucial for antidepressant processing

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In contrast, NMDARs and SYT1 nanoclusters are organized somewhat independently of each other
