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Supporting this pathway may help alleviate symptoms associated with mitochondrial impairment in chronic conditions: Profound Cellular Fatigue: By fueling the Preiss-Handler pathway, niacin provides the necessary NAD+ coenzymes for the mitochondrial electron transport chain to efficiently generate ATP, the body's energy currency

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Graphpad Prism 8 (GraphPad Software, San Diego, CA, United States) was applied for statistical analysis

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Biomarker-guided tailored therapy in major depression

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