michael-type acceptor reactivity toward glutathione Thiol-Michael addition based conjugate for activation and release Michael Addition Reaction Mechanism -
Description
Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition

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doi: 10.1189/jlb.0409236 96 MorhardtTLHayashiAOchiTQuirsMKitamotoSNagao-KitamotoHet al
