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Nonetheless, comprehensive investigations into systemic dysfunctions of mitochondria-organelle interactions in the context of ovarian aging remain limited

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Seddon J.M., Ajani U.A., Sperduto F.L.D., Hiller R., Blair N., Burton T.C., Farber M.D., Gragoudas E.S., Haller J., Miller D.T., et al

Am J Transplant (2011) 11:67280

This unique ability to hydrolyze O6-methyl-dGTP, highly conserved across evolution, is distinctive to MTH1 among human NUDIX enzymes ( To elucidate MTH1s recognition and hydrolysis mechanisms, researchers have resolved its crystal structure using X-ray crystallography (Svensson et al., 2011)