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Traumatic endplate damage also causes necrotic cell death 13 and the release of intracellular contents, including many pro-inflammatory compounds known as damage-associated molecular patterns (DAMPs)

Histamine and receptors in neuroinflammation: Their roles on neurodegenerative diseases

Vitamins B6 and B12 are often used in the injections, but other compounds used include inotisol, choline and methionine