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Keywords: alcohol dependence, alcohol withdrawal syndrome, neuroadaptations, neurochemical adaptations, glutamate, GABA, monoamines, neuropeptides, ion channels INTRODUCTION Alcohol abuse and alcoholism are significant public health concerns that continue to exact enormous burdens on the healthcare industry as well as producing a broad range of societal problems, including judicial (e.g., crime), economic (e.g., damage/loss of property, reduced productivity in the workplace) and, most tragically, collateral damage to personal/family relationships

Besides, ESCRT-III (endosomal sorting complex required for transport III)-dependent membrane repair mechanisms can hinder ferroptosis

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Wegovy (semaglutide 2.4 mg) is a glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to a reduced-calorie diet and increased physical activity