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Description
M1 macrophages express high level of MHC-II, CD86, CD40, inducible nitric oxide synthase (iNOS) and produce reactive oxygen species (ROS), MCP-1, TNF, IL-1, IL-12 and IL-6

What we know about extended use The longest controlled human trials ran for 12 weeks

2f), indicating a lack of biological effects of bearing pressure

Arbor et al., 2019)
