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Figure 3 3.2 Copper-induced cellular necrosis Cellular necrosis represents another form of cell death, characterized by the disruption of normal cellular metabolism due to various causes, leading to morphological alterations and culminating in cell lysis and destruction, a process known as necrosis ( As previously mentioned, copper can participate in redox reactions, generating reactive oxygen species (ROS), such as superoxide and hydroxyl radicals ( 3.3 Copper-induced cellular autophagy Copper-induced autophagy is an intricate biological mechanism, whereby cells stimulate an autophagic response to counteract excessive internal copper

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The intricate, non-linear interactions between environmental pollutants and the genome, epigenome, transcriptome, epitranscriptome, proteome, and metabolome result in adverse health outcomes [2]